Npgrj_ni_1505 1060..1066

نویسندگان

  • Gabrielle T Belz
  • Sammy Bedoui
  • Fiona Kupresanin
  • Francis R Carbone
  • William R Heath
چکیده

Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8 a-chain (CD8a) are localized permanently in lymphoid organs, whereas ‘tissue-derived DCs’ remain in nonlymphoid tissues until they ‘capture’ antigen and then move to local lymph nodes. Here we show that after lung infection, both naive and memory CD8+ ‘killer’ T cells responded to influenza virus antigens presented by lymph node–resident CD8a+ DCs, but only naive cells responded to antigens presented by lung-derived DCs. This difference provides a mechanism for priming naive T cell responses in conditions in which robust memory predominates. Our findings have implications for immunity to pathogens that can mutate their T cell epitopes, such as influenza virus and human immunodeficiency virus, and challenge the long-held view that memory T cells have less-stringent requirements for activation than naive T cells have.

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تاریخ انتشار 2007